Association between coronary artery disease and responsiveness of aortic stiffness and pulsatile diameter change to nitroglycerin
Ibrahim Yildiz1, Pinar Ozmen Yildiz1, Veli Gokhan Cin2
1Osmaniye State Hospital Cardiology Clinic, Osmaniye, Turkey
2Mersin University, Faculty of Medicine, Department of Cardiology, Mersin, Turkey
Aim: This study aimed to evaluate the difference between the effect of nitroglycerin on the aortic stiffness measured by transthoracic M-mode ultrasonography in patients with and without coronary artery disease (CAD).
Material and Methods: This study was conducted on one hundredpatients with a presume diagnosis of CAD. The patients who had a SYNTAX score (SS) ≥1 according to the results of coronary angiography constituted the CAD group (n:60), while patients who had a SS=0 constituted the control group (n:40).The stiffness of the ascending aorta and arterial blood pressure were measured before and 10 minutes after the sublingual administration of 800 mcg nitroglycerin. A comparison of each parameter before and after nitroglycerin was evaluated for statistical significance using paired sample t-test.
Results: In the control group, after nitroglycerin administration, there was a statistically significant reduction in the pulsatile diameter change (from 2.30±0.79 to 1.74±0.91) and significant increase in stiffness index (from 6.24±2.41 to 9.07±5.88). In the CAD group, after nitroglycerin administration, there wasno statistically significant difference in terms of pulsatile diameter change (from 1.42±0.88 to 1.28±0.68) and stiffness index (from 13.52±7.64 to 13.10±7.85).
Conclusion: The effect of nitroglycerin on the aortic stiffness measured by transthoracic M-mode ultrasonography differs in the CAD and control groups. Our findings warrant further studies with a larger population to describe the practicability of this method for the CAD diagnosis.