Is there a predictive association between vitamin D concentrations and lower respiratory tract infections in infants?
Cigdem El1, Mehmet Emin Celikkaya2
1Mustafa Kemal University, Tayfur Ata Sokmen Faculty of Medicine, Department of, Pediatric, Hatay, Turkey
2Mustafa Kemal University, Tayfur Ata Sökmen Faculty of Medicine, Department of, Pediatric Surgery, Hatay, Turkey
Aim: Vitamin D deficiency have been estimated to be endemic in the worldwide and in each age group and also it is reported that vitamin D has important effects on both natural and acquired immunity and there may be a relationship between deficiency and predisposition to infections The aim of this study is to investigate whether serum vitamin D level are effective in infant lower respiratory tract infection which is one of the most mortal infectious diseases in worldwide.
Material and Methods: In our study, between October 2016 and January 2018 in Department of Pediatrics, the data of 418 infants with LRTI and their ages ranging from 5 to 24 months and were examined retrospectively. Vitamin D levels were studied in 106 of this patients.
Results: In group-1, the mean duration of vitamin D supplementation was 4.9 months, while the mean in group-2 was 8.6 months.Breastfeeding time was 3.27 months in group 1 while it was 5.71 months in group 2. Both the duration of breastfeeding and the duration of vitamin D supplementation were shorter in group 1 than in group 2.Those difference between the groups was in terms of statistically significant (p< 0.05)
Conclusion: Vitamin D deficiency in infants may be associated with LRTI, and even vitamin D deficiency may be a predisposing factor for severe LRTIs and also the frequency and severity of LRTIs can be reduced with optimal serum levels of vitamin D.