Cancer is seen more in older female patients with psoriasis : A cross-sectional study in 1551 patients
Habibullah Aktas1, Cansu Serifoglu2
1Karabuk University, Faculty of Medicine, Department of Dermatology, Karabuk, Turkey
2Karabuk University, Faculty of Medicine, Department of Family Medicine, Karabuk, Turkey
Aim: The aim of this study was to establish the potential risk of the development of malignancy in the patients with psoriasis.
Material and Methods: A retrospective analysis of psoriasis cases between January 2017 to August 2018 attending the dermatology clinic at Karabuk Research and Training Hospital was carried out. Patients with psoriasis were screened whether they have any malignant disease and associated chronic disease including diabetes mellitus and hypertension by using hospital data system. Suspected cases regarding psoriasis or malignant disease were excluded. Findings were compared according to demographic characteristics of the patients.
Results: A total of 1551 patients with psoriasis was evaluated in the study time. 30 patients (22 women, 8 men) were found to have malignancy. The most commonly seen malignancy was stomach cancer in women and prostate cancer in men. 2% of patients with psoriasis had cancer. This rate was 2.5% in female patients and 1% in male patients (p <0.005). The mean age of psoriatic patients with cancer was 58.3 years , higher than 41.9 years which is the mean age of all psoriasis patients in the study (p <0.005). The cancer cases were more common in psoriasis patients having diabetes and/or hypertension in comparison with those without diabetes and/or hypertesion (p <0.005).
Conclusion: Cancer was found to be more common in female patients with psoriasis particularly in older age group. In addition, diabetes and hypertension have significant contribution to occurrence of the malignancy in patients with psoriasis.