Gastrointestinal amyloidosis occurring in three different patterns: Case series
Ali Riza Caliskan1, Yasir Furkan Cagin1, Yilmaz Bilgic1, Oguzhan Yildirim1, Mehmet Ali Erdogan1, Yuksel Seckin1,
Saadet Alan2, Nese Karadag Soylu2
1Inonu University, Faculty of Medicine Department of Gastroenterology, Malatya, Turkey
2Inonu University, Faculty of Medicine, Department of Medical Pathology, Malatya, Turkey
Systemic amyloidosis is a rare disease characterized by extracellular accumulation of amyloid protein in one or more organs. In patients with systemic amyloidosis, the most frequently affected organs are kidney and heart, followed by the nervous system, soft tissues, and lungs. Small bowel and liver involvement are also frequent in systemic amyloidosis. Gastrointestinal (GI) findings are common, and the degree of organ involvement determines the symptoms. Patients usually have nonspecific findings such as abdominal pain, nausea, diarrhea, and dysphagia, which may delay the appropriate diagnosis. Liver involvement occurs in the majority of patients, but the symptoms typically do not happen unless a marked hepatic amyloid deposition occurs. Diagnosis is by tissue biopsy. Treatment and prognosis depend on the underlying disease. GI system involvement is a sign of poor prognosis. In this case series, five patients who were diagnosed with gastrointestinal system amyloidosis in our clinic are presented.