@article{Gezer_Altunisik Toplu_Yuksel_Kose_Memisoglu_Ozden_Bayindir_Ersoy_2022, title={Evaluation of CD4/CD8 ratio in treatment follow-up of patients with HIV diagnois in an infection clinic}, volume={29}, url={http://www.annalsmedres.org/index.php/aomr/article/view/4168}, abstractNote={<p><strong>Aim:</strong> Antiretroviral therapy (ART) regimens used in the treatment of HIV are assumed to suppress the virus in plasma indefinitely and restore CD4 lymphocyte count. There is increasing evidence that a reversed CD4/CD8 ratio is associated with immune dysfunction, even in patients who have achieved virological suppression with ART and have elevated CD4 lymphocytes. The CD4/CD8 ratio has emerged as a guiding marker as an indicator of immunoactivation in HIV-infected patients. It was aimed to evaluate the CD4/CD8 ratio of HIV-diagnosed patients at baseline and at follow-up after ART regimen.</p> <p><strong>Materials and Methods:</strong> A total of 150 patients were included in the study by retrospectively scanning the CD4/CD8 ratio at the initial and 24th week of follow-up in patients who were diagnosed with HIV and started treatment in the Infectious Diseases and Clinical Microbiology Clinic of the Hospital of the Medical Faculty between 2011-2021. ART treatment regimens were divided into three groups as nucleoside reverse transcriptase inhibitor (NRTI)+protease inhibitor (PI), NRTI+non-nucleoside reverse transcriptase inhibitor (NNRTI) or NRTI+ integrase strand transfer inhibitor (INSTI).</p> <p><strong>Results: </strong>A total of 150 patients were included in the study. While the initial CD4/CD8 ratio of the patients was 0.36, it increased to 0.61 at the 24th week of treatment. Among the 144 patients whose baseline values were CD4/CD8<1, the rate of the ones who achieved CD4/CD8≥1 value at week 24 after ART regimens was found as 13.2% (19/144). It was observed that the CD4/CD8 ratio in the group receiving INSTI was higher (15.1%) than those of the other groups. The undetectable HIV RNA level after treatment was significantly mostly observed in the group, receiving the integrase-based regimen, with 77.1%. With effective ART, CD4/CD8 normalization is higher in individuals with high CD4 T cell counts before treatment. There was a significant increase in the CD4/CD8 ratio in all three ART regimen groups. However, most of the patients who achieved a CD4/CD8 ratio ≥1 were in the INSTI-based ART group.</p> <p><strong>Conclusion: </strong>The CD4/CD8 ratio may contribute to clinical evaluation in long-term follow-up as a marker of immunological response in individuals treated with a diagnosis of HIV.</p>}, number={7}, journal={Annals of Medical Research}, author={Gezer, Yakup and Altunisik Toplu, Sibel and Yuksel, Mustafa and Kose, Adem and Memisoglu, Funda and Ozden, Mehmet and Bayindir, Yasar and Ersoy, Yasemin}, year={2022}, month={Jul.}, pages={743–747} }