Annals of Medical Research
type: channel
publisher: Inonu University
language: en
publication name: Annals of Medical Research
issn: 2636-7688
copyright: CC Attribution-NonCommercial-NoDerivatives 4.0
items: Intraventricular migration of intraocular silicone oil: A rare case with computed tomography and magnetic resonance imaging findings
items: Evaluation of clinical, radiological characteristics, and treatment outcomes of pediatric pseudotumor cerebri syndrome cases
items: A comparative study of nerve-sparing techniques in open radical prostatectomy: Antegrade versus retrograde
items: Risk of hepatitis B reactivation in rheumatic patients receiving tocilizumab treatment
items: Efficacy of combined screening tests used in the first trimester in predicting adverse pregnancy outcomes
items: A resveratrol-loaded scaffold enhances tendon healing: Histological and biomechanical analysis in a rat Achilles tendon repair model
items: Should videolaryngoscopy enter routine use? Unanticipated difficult airway: A five-year experience in a tertiary care hospital
items: Diagnostic and prognostic utility of systemic inflammation indices in cervical dysplasia
items: Functional and radiological comparison of lateral pinning versus cross pinning in displaced pediatric supracondylar humerus fractures
items: Effect of methylphenidate treatment on macula and optic disc microvascularity in children with attention-deficit/hyperactivity disorder: A retrospective study
items: Evaluation of risk factors for morbidity and mortality in intensive care unit readmissions
items: Role of loneliness in the relationship between chronic pain and analgesic use in the elderly
items: Impact of reflux, bruxism, age, and plaque index on anterior tooth wear: A cross-sectional clinical evaluation
items: The relationship between health literacy and digital healthy diet literacy and dietary habits of pregnant women in different trimesters
items: First-trimester screening markers in pregnancies complicated by cervical insufficiency: A comparative retrospective study
items: The relationship between lung involvement in rheumatoid arthritis and sarcopenia
items: Evaluation of patient-related factors and index treatment in recurrent ingrown toenail cases
items: Determination of density ranges to be used in grading hepatosteatosis using computed tomography
items: A novel benzamide derivative SY-15 inhibits multiple myeloma cell proliferation
items: Intersphincteric anal abscess, a rare cause of axial low back pain: A case report
items: Rim enhancement, drainage, and inflammatory response in patients with anterior versus posterior lingual abscesses
items: Functional neurological (conversion) symptoms mediate the effect of self-stigma in women seeking psychological help on their psychological well-being
items: Comparison of patients undergoing general anesthesia or ultrasonography-guided interscalene block in shoulder surgery in terms of postoperative analgesia: A retrospective study
items: An increase in neuropathic complaints corresponds to the severity of central sensitization-related symptoms in women with fibromyalgia: A cross-sectional study
items: Examining the relationship between sustainability consciousness and physical activity in healthy young adults
items: Investigation of the prognostic impact of proline-rich protein 11 (PRR11) transcription levels in early-stage bladder cancer
items: Evaluation of clinical and demographic characteristics of elderly patients receiving inpatient treatment in a university hospital psychiatry clinic
items: Efficacy of therapeutic plasma exchange in HELLP syndrome: A single-center experience
items: The effect of music to sleep quality on liver transplanted patients
items: Analysis of intestinal parasitic infections seen in the Southeastern Anatolia Region tertiary hospital between 2019-2024

Intraventricular migration of intraocular silicone oil: A rare case with computed tomography and magnetic resonance imaging findings
type: item
description: Intraocular silicone oil (SiO) is widely used as a long-term internal tamponade agent in the surgical treatment of various vitreoretinal disorders. A rare but diagnostically critical complication of SiO is its migration into the brain ventricles. Although few such cases have been reported, this condition may mimic serious pathologies, such as intraventricular hemorrhage. In this case report, intraventricular migration of SiO was identified in an 81-year-old woman with a history of vitreoretinal surgery for diabetic retinopathy–related retinal detachment. The patient presented with dizziness, imbalance, and nausea, and neuroimaging revealed hyperdense layering within the bilateral frontal horns on noncontrast brain computed tomography. These findings may mimic acute intraventricular hemorrhage, highlighting the importance of clinical and radiological correlation for accurate differential diagnosis. Additionally, the patient was concurrently diagnosed with a cerebellar infarction. Awareness of this rare complication may help prevent unnecessary interventions and potential treatment errors in patients presenting with stroke-like symptoms.
subject: Case Reports
  topic: section
subject: Intraventricular migration
  topic: keywords
subject: Silicone oil
  topic: keywords
subject: Retinal surgery
  topic: keywords
subject: Intraventricular silicone oil
  topic: keywords
subject: Neuroimaging
  topic: keywords
creator: Ali Salbas
creator: Bilgenur Aksoy
creator: Mustafa Fazil Gelal
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-25
publication date: 2025-11-25
starting page: 518
ending page: 520

Evaluation of clinical, radiological characteristics, and treatment outcomes of pediatric pseudotumor cerebri syndrome cases
type: item
description: Aim: This study aims to evaluate the clinical, radiological, and treatment outcomes of pediatric patients diagnosed with Pseudotumor Cerebri Syndrome. Materials and Methods: This retrospective study included 21 children diagnosed with definite or possible Pseudotumor Cerebri Syndrome according to the revised Friedman diagnostic criteria, out of 115 patients evaluated between 2017 and 2019 at a pediatric neurology clinic. Clinical findings, radiological features, treatment responses, and prognosis were analyzed. Results: The study cohort was predominantly female (85.7%), with a mean age of 12.8 years. The most common presenting symptoms were headache, visual disturbances, and vomiting. A key diagnostic finding was elevated cerebrospinal fluid (CSF) opening pressure (>280 mmH₂O), observed in 67% of patients. Two-thirds of the cases (66.6%) were classified as Primary Pseudotumor Cerebri Syndrome, while the remaining third (33.4%) were secondary, most frequently attributed to drug exposure or vitamin imbalances. The majority of patients showed significant clinical improvement following medical treatment with high-dose acetazolamide. Only a few required adjunctive therapies such as topiramate or corticosteroids, and recurrence was documented in only a single case. Additionally, MRI findings supportive of the diagnosis were present in a subset of patients. Conclusion: Early diagnosis and treatment of Pseudotumor Cerebri Syndrome in children can prevent permanent visual complications. A multidisciplinary approach, including ophthalmology and pediatric neurology, is essential for accurate diagnosis, effective treatment, and favorable outcomes.
subject: Original Articles
  topic: section
subject: Pseudotumor cerebri syndrome
  topic: keywords
subject: Pediatric neurology
  topic: keywords
subject: Increased intracranial pressure
  topic: keywords
subject: Acetazolamide treatment
  topic: keywords
subject: Papilledema
  topic: keywords
creator: Arzu Eroglu
creator: Demet Aydogdu
creator: Ahmet Guven
creator: Huseyin Caksen
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-25
publication date: 2025-11-25
starting page: 506
ending page: 511

A comparative study of nerve-sparing techniques in open radical prostatectomy: Antegrade versus retrograde
type: item
description: Aim: To compare perioperative, oncological, and functional outcomes between antegrade and retrograde nerve-sparing techniques in open radical prostatectomy (ORP). Materials and Methods: This retrospective study included 278 patients who underwent open radical prostatectomy (ORP) performed by a single surgeon between 2016 and 2025. Patients were divided based on the nerve-sparing approach: antegrade (n=90) or retrograde (n=188). Demographic characteristics, perioperative variables, pathological outcomes, biochemical recurrence (BCR), urinary continence, and erectile function were evaluated. Multivariable logistic regression analysis was used to determine independent predictors of BCR. Results: Retrograde ORP demonstrated a shorter operative time compared with the antegrade technique (151.1 vs. 166.5 minutes, p<0.001), whereas the antegrade group was associated with lower intraoperative blood loss (437 vs. 517 mL, p=0.047). Biochemical recurrence was significantly higher in the antegrade group (33.3% vs. 18.8%, p=0.008). Postoperative functional outcomes, including urinary continence (p=0.524) and erectile function (p=0.230), were comparable between the groups. In multivariable logistic regression, the retrograde approach independently reduced the risk of biochemical recurrence (OR 0.38; 95% CI: 0.19–0.76; p=0.0058). Conclusion: It is evident that both techniques are safe and effective in ORP. The retrograde approach was associated with more favourable oncological outcomes, whereas the antegrade technique provided better intraoperative hemostasis. The choice of surgical approach should be individualized based on tumor characteristics and surgeon expertise.
subject: Original Articles
  topic: section
subject: Prostatectomy
  topic: keywords
subject: Nerve-sparing
  topic: keywords
subject: Prostate cancer
  topic: keywords
subject: Open surgery
  topic: keywords
subject: Biochemical recurrence
  topic: keywords
creator: Serkan Ozcan
creator: Hakan Tekinaslan
creator: Osman Kose
creator: Enis Mert Yorulmaz
creator: Sacit Nuri Gorgel
creator: Yigit Akin
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-25
publication date: 2025-11-25
starting page: 499
ending page: 505

Risk of hepatitis B reactivation in rheumatic patients receiving tocilizumab treatment
type: item
description: Aim: This study aimed to investigate the relationship between tocilizumab, a biological agent widely used for treating rheumatic diseases, and hepatitis B virus reactivation (HBVr). Materials and Methods: The electronic records of all patients who received tocilizumab in our rheumatology outpatient clinic between July 2018 and August 2024 were retrospectively reviewed. Demographic data, baseline and followup HBV serological markers, liver biochemistry, and antiviral prophylaxis details were extracted and analyzed. Results: A total of 54 patients were included (76.2 % female; mean age 57.5 ± 14.3 years). While HBsAg, anti-HBc IgGG and anti-HBs were requested for all patients before treatment, HBsAg was positive in 1 of 54 patients (1.9%) and anti-HBc IgG was positive in 26 (48.1%). While antiviral treatment was initiated in 10 (18.5%) of the patients, 9 were HBsAg negative, 1 was HBsAg positive, and 1 was anti-HBc Ig G positive. No patient experienced HBV reactivation during treatment; however, one HBsAg-positive patient achieved HBsAg seroclearance. The mean follow-up period was 50.5 ± 22.9 months. Conclusion: No patient experienced HBV reactivation during tocilizumab therapy, and a single HBsAgpositive participant on prophylactic tenofovir achieved HBsAg seroclearance. These realworld data suggest that HBsAgnegative/antiHBcpositive individuals may be managed with vigilant biochemical and serological monitoring rather than routine antiviral prophylaxis during tocilizumab treatment. Nevertheless, the retrospective singlecentre design and modest sample size limit the strength and generalizability of these findings; larger prospective studies are required for definitive guidance.
subject: Original Articles
  topic: section
subject: Rheumatological disease
  topic: keywords
subject: Tocilizumab
  topic: keywords
subject: Hepatitis B virus reactivation
  topic: keywords
creator: Bayram Kizilkaya
creator: Osman Cure
creator: Serdar Durak
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-25
publication date: 2025-11-25
starting page: 512
ending page: 517

Efficacy of combined screening tests used in the first trimester in predicting adverse pregnancy outcomes
type: item
description: Aim: This study aims to evaluate the predictive efficacy of first-trimester screening test parameters, including free β-human chorionic gonadotropin (β-hCG), pregnancy-associated plasma protein-A (PAPP-A), and nuchal translucency (NT), in identifying adverse pregnancy outcomes such as gestational diabetes mellitus (GDM), fetal growth restriction (FGR), preeclampsia, preterm birth, and placenta accreta spectrum (PAS) or placenta previa (PP). Materials and Methods: A retrospective cohort analysis involved 776 pregnant women who underwent first-trimester screening tests between January 2023 and August 2024. Patients were categorized into two groups based on the presence or absence of pregnancy complications. Results: Pregnancy complications were identified in 36.6% of participants, with GDM, FGR, and preterm birth being the most common. PAPP-A levels were significantly reduced in pregnancies complicated by GDM (p=0.033), FGR (p=0.048), and preeclampsia (p=0.001). NT values were notably elevated in GDM cases (p=0.016). Free β-hCG levels were significantly higher in preterm birth (p=0.040) and PAS/PP cases (p=0.016). ROC analysis revealed notable predictive thresholds: PAPP-A <0.64 for preeclampsia (AUC=0.760, p=0.001) and β-hCG >1.01 for PAS/PP (AUC=0.814, p=0.016). Conclusion: First-trimester screening test parameters, particularly PAPP-A, NT, and β-hCG, exhibit potential in predicting adverse pregnancy outcomes. Reduced PAPP-A levels correlate with GDM, FGR, and preeclampsia, while elevated NT and β-hCG levels are associated with GDM and PAS/PP, respectively. Although these markers demonstrate promise, larger-scale prospective studies are needed to confirm their clinical utility and reliability in predicting pregnancy complications.
subject: Original Articles
  topic: section
subject: First trimester screening
  topic: keywords
subject: Pregnancy complications
  topic: keywords
subject: Gestational diabetes mellitus
  topic: keywords
subject: Preeclampsia
  topic: keywords
subject: Fetal growth restriction
  topic: keywords
subject: Placenta accreta spectrum
  topic: keywords
creator: Ruken Dayanan
creator: Gizem Aktemur
creator: Betul Tokgoz Cakir
creator: Gulsan Karabay
creator: Ahmet Arif Filiz
creator: Nazan Vanli Tonyali
creator: Merve Ayas Ozkan
creator: Dilara Duygulu Bulan
creator: Mevlut Bucak
creator: Hatice Ayhan
creator: Ali Turhan Caglar
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-24
publication date: 2025-10-24
starting page: 465
ending page: 473

A resveratrol-loaded scaffold enhances tendon healing: Histological and biomechanical analysis in a rat Achilles tendon repair model
type: item
description: Aim: This study aims to evaluate the effects of Dermalix® (Dx), a resveratrol-loaded, bioabsorbable scaffold composed of collagen, laminin, and hyaluronic acid, on tendon healing and peritendinous adhesion formation following primary Achilles tendon repair in a rat model. Materials and Methods: A total of 28 female Wistar Albino rats underwent bilateral Achilles tendon injury and repair using the modified Kessler technique. The right legs were treated with local Dx application over the repair site, while the left legs served as untreated controls. Animals were randomly assigned to one of four groups (n = 7 per group). The groups were defined by the evaluation time point (3 or 6 weeks) and the type of analysis (histological or biomechanical). Assessments included macroscopic adhesion scoring, histological quantification (counts of fibroblasts, fibrocytes, and vessels), and biomechanical testing (maximum load to failure and elongation at rupture). Statistical comparisons were made using t-test, Mann-Whitney U, chi-square , ANOVA, or the Friedman test, as appropriate for the data. Results: Dx application significantly reduced severity of adhesion at both 3 and 6 weeks (p<0.01). Histological analyses revealed significantly lower fibroblast and fibrocyte counts with more organised collagen alignment in Dx-treated groups (p<0.05). Biomechanically, rupture force was significantly higher in Dx groups at both time points (p<0.01 and p=0.029), while no significant difference was found in elongation distance. The scaffold was resorbed by week 3, without inducing any foreign body reaction or systemic side effects. Conclusion: The local application of Dx enhanced tendon healing significantly and reduced peritendinous adhesions without compromising biomechanical strength. Its bioabsorbable composition and local antioxidant properties make Dx a promising supportive local treatment option in tendon repair surgery. This is particularly valid in cases with high adhesion risk.
subject: Original Articles
  topic: section
subject: Resveratrol
  topic: keywords
subject: Bioabsorbable scaffold
  topic: keywords
subject: Tendon healing
  topic: keywords
subject: Peritendinous adhesion
  topic: keywords
subject: Achilles tendon
  topic: keywords
subject: Dermalix®
  topic: keywords
creator: Oguzhan Gokalp
creator: Gokay Eken
creator: Erkan Bilgin
creator: Ezgi Yumusak
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-24
publication date: 2025-10-24
starting page: 457
ending page: 464

Should videolaryngoscopy enter routine use? Unanticipated difficult airway: A five-year experience in a tertiary care hospital
type: item
description: Aim: An unanticipated difficult airway (UDA) can be very challenging for anesthesiologists in airway management and, if not managed appropriately, may lead to increased morbidity and even mortality in patients. Because patients with normal physical examination findings may also have a difficult airway, meticulous preparations are essential for every patient. Our study investigated the five-year outcomes of a tertiary care hospital in patients with UDA. Materials and Methods: We retrospectively reviewed the records of 143 patients with UDA who underwent surgery under general anesthesia between January 2020 and March 2025. We evaluated their airway management: preoperative physical examination findings, demographics, comorbidities, mask ventilation, laryngoscopic visualization, and tracheal intubation success. Results: We found that videolaryngoscopy (VL) improved glottic visualization compared to direct laryngoscopy (DL) in patients with UDA (p<0.001). VL reduced the risk of complications and accidental esophageal intubation compared to DL (p<0.001, p<0.001, respectively). We also found that 129 out of 133 patients (97%) who could not be intubated with DL were successfully intubated endotracheally using VL. Conclusion: VL improves glottic visualization, reduces the risk of complications, and increases the rate of successful intubation compared to DL in patients with UDA.
subject: Original Articles
  topic: section
subject: Anesthesia
  topic: keywords
subject: Airway management
  topic: keywords
subject: Difficult airway
  topic: keywords
subject: Intubation
  topic: keywords
subject: Laryngoscopy
  topic: keywords
subject: Videolaryngoscopy
  topic: keywords
creator: Ali Genc
creator: Ahmet Tugrul Sahin
creator: Mehtap Gurler Balta
creator: Vildan Kolukcu
creator: Hakan Tapar
creator: Tugba Karaman
creator: Serkan Karaman
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-24
publication date: 2025-10-24
starting page: 450
ending page: 456

Diagnostic and prognostic utility of systemic inflammation indices in cervical dysplasia
type: item
description: Aim: This study investigated the diagnostic and prognostic potential of the Systemic Immune Inflammation Index (SII), Neutrophil Lymphocyte Ratio (NLR), and Platelet Lymphocyte Ratio (PLR) in cervical dysplasia, evaluating their correlation with disease presence and severity for potential clinical applications in risk assessment and patient management. Materials and Methods: In this retrospective study, the SII, NLR, and PLR values were analyzed using parameters obtained from the routine complete blood count of 215 patients whose cervical dysplasia grades were evaluated through colposcopic biopsy. Results: HPV DNA types 16 and 18 were detected in 114 (53.0%) of 215 patients, while 101 (47.0%) tested positive for non-16/18 hr-HPV DNA types. No statistically significant differences were observed in WBC, neutrophil, platelet, lymphocyte, SII, NLR, and PLR values across the chronic cervicitis, LSIL (low-grade squamous intraepithelial lesion), and HSIL (high-grade squamous intraepithelial lesion) groups (p < 0.05). However, logistic regression analysis for HSIL risk identified lymphocyte count (OR = 0.998) and PLR (OR = 0.975) as significant predictors, where a one-unit increase in each was associated with a 0.2% and 2.5% decrease in the odds of HSIL, respectively. Conclusion: SII, NLR, and PLR values in diagnosing or grading the presence or severity of cervical dysplasia, indicating that these systemic inflammatory markers alone may have limited value as diagnostic or prognostic tools. Further validation through larger prospective studies is warranted to more comprehensively elucidate the role of these markers.
subject: Original Articles
  topic: section
subject: Systemic immune inflammation index
  topic: keywords
subject: Platelet-lymphocyte ratio
  topic: keywords
subject: Neutrophil-lymphocyte ratio
  topic: keywords
subject: Complete blood count
  topic: keywords
subject: Cervical intraepithelial neoplasia
  topic: keywords
creator: Yagmur Soykan
creator: Ahmet Elturk
creator: Cennet Meltem Alaybeyoglu
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-25
publication date: 2025-11-25
starting page: 493
ending page: 498

Functional and radiological comparison of lateral pinning versus cross pinning in displaced pediatric supracondylar humerus fractures
type: item
description: Aim: The aim of this study is to compare the commonly used cross pinning and lateral pinning techniques in the surgical treatment of pediatric supracondylar humerus fractures by evaluating clinical and radiological outcomes. Materials and Methods: Between 2018 and 2024, patients who had surgical treatment for Gartland type 3 supracondylar humerus fractures were included in the study. Patients were divided into two groups based on the surgical technique: lateral pinning (Group 1) and cross pinning (Group 2). Patients with a minimum folloe-up of 6 months were included in the study. Demographic data inlcuidng age, sex, side, mechanism of trauma were recorded. Clinical evaluation was performed using Flynn’s criteria. Radiological evaluation included assessment of fracture union, Baumann’s angle and its change from 0 to 6 months, carrying angle, lateral humerocapitellar angle (LHCA), and its 0 to 6-month change. Complications and additional procedures were also recorded. Results: Group 1 consisted of 32 patients, while Group 2 included 28 patients. The demographic data showed no statistically significant differences between the two groups. Based on Flynn’s criteria, outcomes in Group 1 were classified as excellent in 24 (75%) patients, good in 5 (15.6%), fair in 3 (9.4%), and none were considered poor. In Group 2, 20 (71.4%) patients achieved excellent results, 7 (25%) were rated as good, 1 as fair (3.6%), and no poor outcomes were observed. Functional outcomes were similar in both groups (p: 0.488). The groups showed comparable results in terms of both the Baumann’s angle and its change, carrying angle, LHCA and its change. Ulnar nerve injury developed in 2 patients in Group 2 and resolved with conservative follow-up. Conclusion: In the management of pediatric supracondylar humerus fractures, lateral and cross pinning techniques yield comparable clinical and radiological results. To prevent ulnar nerve palsy in the cross-pinning technique, a mini medial incision can be …
subject: Original Articles
  topic: section
subject: Gartland
  topic: keywords
subject: Pediatric
  topic: keywords
subject: Pinning
  topic: keywords
subject: Supracondylar
  topic: keywords
creator: Baris Acar
creator: Saltuk Bugra Tekin
creator: Ahmet Sinan Kalyenci
creator: Ahmet Senel
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-25
publication date: 2025-11-25
starting page: 481
ending page: 485

Effect of methylphenidate treatment on macula and optic disc microvascularity in children with attention-deficit/hyperactivity disorder: A retrospective study
type: item
description: Aim: This study aimed to investigate macular and optic nerve head (ONH) microvascularization in children diagnosed with attention deficit hyperactivity disorder (ADHD) before and 6 months after the initiation of methylphenidate (MPH) treatment, and to compare these findings with a healthy control group. Materials and Methods: This retrospective study included 66 eyes of 66 patients with ADHD and 74 eyes of 74 healthy controls, all aged 6–17 years. Participants were grouped as follows: newly diagnosed treatment-naive ADHD patients, the same patients after 6 months of MPH treatment, and healthy controls. Specular microscopy findings, pupil size (PS), anterior chamber depth (ACD), and lens thickness (LT) values of participants were recorded. Additionally, retinal nerve fiber layer (RNFL) thickness, central macular thickness (CMT), and optic nerve head (ONH) radial peripapillary capillary plexus (RPCP), superficial capillary plexus (SCP), and deep capillary plexus (DCP) vessel density (VD) parameters were measured. Results: Statistically significant increases in whole-image VD values for SCP and DCP were observed following MPH treatment (both p < 0.001). Additionally, SCP VD values were significantly lower in treatment-naive children with ADHD compared to healthy controls, while RPCP VD values were higher (p = 0.006 and p = 0.010, respectively). No statistically significant differences in CMT, RNFL thickness, or anterior segment parameters (PS, ACD, LT) were observed either after MPH treatment within the ADHD group or between the control group and treatment-naive ADHD patients. Conclusion: In children diagnosed with ADHD, significant increases in SCP and DCP values were observed following MPH treatment. These findings indicate the need for further studies to evaluate the effects and clinical significance of MPH treatment on retinal microvasculature.
subject: Original Articles
  topic: section
subject: Attention deficit hyperactivity disorder
  topic: keywords
subject: Methylphenidate
  topic: keywords
subject: Optical coherence tomography angiography
  topic: keywords
creator: Serhat Ermis
creator: Duygu Kinay Ermis
creator: Yusuf Cem Yilmaz
creator: Serife Ciloglu Hayat
creator: Petek Aksoz
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-25
publication date: 2025-11-25
starting page: 474
ending page: 480

Evaluation of risk factors for morbidity and mortality in intensive care unit readmissions
type: item
description: Aim: Unplanned readmissions to the intensive care unit (ICU) are associated with poor clinical outcomes, prolonged hospital stays, and increased healthcare costs. Identifying the clinical and laboratory predictors of ICU readmission and its impact on in-hospital mortality remains critical for improving patient safety and optimizing utilization of the resources. This study aimed to investigate the factors associated with ICU readmission and evaluate its relationship with mortality in a tertiary-care hospital setting. Materials and Methods: In this retrospective cohort study, data of 1347 patients followed in Pulmonary ICU between 2016 and 2024 were retrospectively evaluated. Data of 153 patients (75 patients readmitted and 78 control cases selected randomly who were not readmitted during the same hospitalization) were analyzed. The two groups -those with and without ICU readmission- were compared in terms of demographic characteristics, clinical parameters, comorbidities, nutritional status, and laboratory findings. Logistic regression analysis was used to identify predictors of mortality. Results: Readmitted patients were older (p=0.001), had lower Glasgow Coma Scores (p <0.001), higher APACHE II scores (p <0.001), and longer ICU and hospital stays (p=0.002, p=0.006 respectively). They also required more vasopressors (p=0.004), mechanical ventilation (p=0.001), and sedation (p<0.001). Nosocomial infections were more frequent in this group (p <0.001). Univariate regression analysis revealed that ICU readmission, low serum albumin, nosocomial infections, use of vasopressors, and comorbidities such as dementia and cerebrovascular disease were significantly associated with mortality (p<0.05). In the Backward Wald model, albumin during hospitalization, nosocomial infection and APACHE II scores were independent risk factors for mortality (p<0.05). Conclusion: ICU readmission is strongly associated with adverse clinical outcomes and increased in-hospital mortality. Identif…
subject: Original Articles
  topic: section
subject: Readmission
  topic: keywords
subject: ICU care
  topic: keywords
subject: Risk factors
  topic: keywords
subject: Comorbidity
  topic: keywords
subject: Mortality
  topic: keywords
subject: Morbidity
  topic: keywords
creator: Ayse Capar
creator: Seyma Baslilar
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-24
publication date: 2025-10-24
starting page: 443
ending page: 449

Role of loneliness in the relationship between chronic pain and analgesic use in the elderly
type: item
description: Aim: Loneliness is more frequently observed in older adults than in other age groups and is associated with adverse health outcomes. This study aimed to examine the relationship between loneliness, chronic pain, and analgesic use in the geriatric population. Materials and Methods: This cross-sectional study included 384 elderly subjects who presented to a family medicine outpatient clinic. The University of California, Los Angeles (UCLA) Loneliness Scale for the Elderly and the Geriatric Pain Measure were used to collect data on the variables. Results: The mean age of the 384 elderly participants included in the study was 74.91±7.12 years (range: 65–91). Of the participants, 52.9% were women and 11.7% were living alone. Higher frequencies of analgesic use were associated with higher pain and loneliness scores (p<0.001). A moderate, positive, and statistically significant correlation was found between pain and loneliness scores (r=0.478, p<0.001). In the multivariate linear regression analysis, each 1-point increase in the loneliness score led to a 1.72-point increase in the pain score. Female sex and chronic diseases were associated with 4.63- and 9.65-point increases in the pain score, respectively. Multinomial logistic regression analysis showed that, independent of age, sex, and pain score, each 1-point increase in the loneliness scale score was associated with a higher likelihood of using analgesics ≥15 times/month (OR=1.29), 8–14 (OR = 1.24), and 2–7 (OR = 1.22) times/month. Age and sex did not have any significant effect on monthly analgesic use. Conclusion: There is a positive relationship between loneliness, chronic pain, and frequent use of analgesics in the elderly subjects Psychosocial assessment and support in elderly patients may help reduce excessive analgesic consumption.
subject: Original Articles
  topic: section
subject: Elderly
  topic: keywords
subject: Analgesic
  topic: keywords
subject: Loneliness
  topic: keywords
subject: Pain
  topic: keywords
creator: Adem Taha Ozdemir
creator: Yavuz Korkmaz
creator: Mehmet Beler
creator: Mehmet Kayhan
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-24
publication date: 2025-10-24
starting page: 436
ending page: 442

Impact of reflux, bruxism, age, and plaque index on anterior tooth wear: A cross-sectional clinical evaluation
type: item
description: Aim: This study aims to evaluate the effect of variables such as gastroesophageal reflux disease (GERD), bruxism, plaque index, and age on erosive wear occurring on the palatal surfaces of maxillary anterior teeth, and to objectively measure this wear using the Anterior Clinical Erosive Classification (ACEC). Materials and Methods: A total of 507 individuals were included. Participants completed self-report questionnaires regarding the presence, previous diagnosis, disease duration, and medication use. Bruxism was assessed through self-report and clinical examination. Erosive wear on maxillary anterior teeth palatal surfaces was measured using ACEC, and plaque accumulation using the Silness and Löe Plaque Index. Statistical analyses included independent sample t-tests and Spearman/Pearson correlation coefficients. Significance was set at p<0.05. Results: Reflux disease was detected in 20.9% of the participants in the study. ACEC scores of individuals reporting reflux symptoms were found to be significantly higher compared to healthy individuals (p<0.05). ACEC scores were also found to be significantly higher in individuals with bruxism than those of without bruxism. In contrast, the plaque index did not show a significant difference between the groups. Additionally, a significant and positive relationship was found between the duration of reflux and ACEC scores (r=0.281, p<0.01). ACEC scores were observed to be higher in individuals receiving reflux treatment compared to those not using medication. Conclusion: These findings indicate that reflux affects not only the gastrointestinal system but also oral and dental health and emphasize the importance of early diagnosis and intervention for dental erosion in individuals with reflux symptoms. Our study reveals the usability of the ACEC in large populations and sheds light on the multifactorial etiology of dental erosion. It also highlights the need to consider the potential abrasive effects of medications used in reflu…
subject: Original Articles
  topic: section
subject: Gastroesophageal reflux disease
  topic: keywords
subject: Dental erosion
  topic: keywords
subject: Anterior clinical erosive classification
  topic: keywords
subject: Tooth wear
  topic: keywords
creator: Fikri Ocal
creator: Tuba Sarici
creator: Enis Simsek
creator: Muhammed Furkan Keser
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-09-25
publication date: 2025-09-25
starting page: 415
ending page: 420

The relationship between health literacy and digital healthy diet literacy and dietary habits of pregnant women in different trimesters
type: item
description: Aim: This study aimed to investigate the relationship between health literacy, digital healthy diet literacy, and dietary habits of pregnant women in different trimesters. Materials and Methods: This study included 189 pregnant women who had registered for routine prenatal care. The participants were interviewed about their demographic characteristics, general health, smoking and alcohol consumption, medical history, and general dietary habits. In addition, a questionnaire with the Health Literacy Scale and the Digital Healthy Diet Literacy Scale was completed. Results: A positive, weak, and statistically significant correlation was found between prepregnancy body mass index (BMI) and the Health Literacy Scale (p < 0.05). A positive, weak, and statistically significant relationship was found between health literacy and digital healthy eating literacy (r = 0.278; p = 0.007). Conclusion: As the health literacy of pregnant women improves, so does their digital healthy diet literacy. These results demonstrate the importance of promoting health literacy to support healthy dietary behaviors during pregnancy.
subject: Original Articles
  topic: section
subject: Pregnancy trimesters
  topic: keywords
subject: Health literacy
  topic: keywords
subject: Diet
  topic: keywords
subject: Obesity
  topic: keywords
subject: Women health
  topic: keywords
creator: Halis Dogukan Ozkan
creator: Pinar Gobel
creator: Hilal Dogan Guney
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-09-25
publication date: 2025-09-25
starting page: 408
ending page: 414

First-trimester screening markers in pregnancies complicated by cervical insufficiency: A comparative retrospective study
type: item
description: Aim: This retrospective study aimed to evaluate the relationship between first-trimester screening markers and cervical insufficiency, comparing biochemical parameters and pregnancy outcomes among women with cervical insufficiency, spontaneous preterm birth, and term pregnancies. Materials and Methods: A total of 248 singleton pregnancies were included and divided into three groups: control (term deliveries, n=121), cervical insufficiency with cerclage (n=60), and spontaneous preterm birth (n=67). First-trimester serum markers including pregnancy-associated plasma protein A (PAPP-A), free beta-human chorionic gonadotropin (β-hCG), nuchal translucency (NT), and alpha-fetoprotein (AFP) were analyzed. Obstetric and neonatal outcomes such as gestational age at delivery, birth weight, Apgar scores, and adverse neonatal outcomes were recorded. Results: No significant differences were observed in first-trimester PAPP-A, β-hCG, NT, and AFP levels between the cervical insufficiency and control groups. However, the spontaneous preterm birth group exhibited significantly lower PAPP-A and higher β-hCG levels compared to both other groups (p < 0.001). Gestational age at delivery, birth weight, Apgar scores, and adverse neonatal outcomes were significantly worse in both cervical insufficiency and spontaneous preterm birth groups compared to controls (p < 0.05). Conclusion: First-trimester biochemical markers have limited predictive value for cervical insufficiency but show significant alterations in spontaneous preterm birth. Cervical insufficiency appears to be a localized structural pathology not reflected by early systemic biochemical changes. Clinical management should prioritize second-trimester cervical length assessment and appropriate interventions over reliance on first-trimester serum markers. Further research is needed to identify specific biomarkers for early detection of cervical insufficiency.
subject: Original Articles
  topic: section
subject: Cervical insufficiency
  topic: keywords
subject: First-trimester screening
  topic: keywords
subject: Beta-human chorionic gonadotropin (β-hCG)
  topic: keywords
subject: Pregnancy-associated plasma protein A
  topic: keywords
creator: Dilara Duygulu Bulan
creator: Gizem Aktemur
creator: Zeynep Seyhanli
creator: Ruken Dayanan
creator: Merve Ayas Ozkan
creator: Gulsan Karabay
creator: Sevki Celen
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-09-25
publication date: 2025-09-25
starting page: 383
ending page: 388

The relationship between lung involvement in rheumatoid arthritis and sarcopenia
type: item
description: Aim: This study investigated the effect of lung involvement in Rheumatoid Arthritis (RA) on sarcopenia. Materials and Methods: A retrospective analysis was conducted on patients with RA diagnosed between January 2020 and January 2024. Patients with non-contrast thoracic CT scans available in the hospital database were included. A control group consisting of individuals without any inflammatory diseases was also selected. Muscle area (MA) and muscle-to-aorta density (M/A density) ratio were compared between the RA and control groups, as well as between RA patients with and without pulmonary involvement. Results: A total of 187 individuals (156 women, 31 men) were included in the study, comprising 84 patients in the RA group and 103 in the control group. The M/A density ratio was significantly lower in the RA group (p<0.001). Among RA patients, 30 (36%) had pulmonary involvement. The M/A density ratio was significantly lower in RA patients with lung involvement compared to those without (p = 0.016). However, the muscle area showed no significant difference among the groups (p = 0.683). Conclusion: This study found that RA lung involvement may be associated with increased muscle adiposity. Prospective studies with large populations are needed to confirm this association.
subject: Original Articles
  topic: section
subject: Rheumatoid Arthritis (RA)
  topic: keywords
subject: Lung involvement
  topic: keywords
subject: Sarcopenia
  topic: keywords
subject: Muscle density
  topic: keywords
subject: Computed Tomography (CT)
  topic: keywords
creator: Enes Gul
creator: Ahmetcan Sevim
creator: Irfan Atik
creator: Seda Atik
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-24
publication date: 2025-10-24
starting page: 429
ending page: 435

Evaluation of patient-related factors and index treatment in recurrent ingrown toenail cases
type: item
description: Aim: This study aims to evaluate patient-related factors and previous treatments in patients with ingrown toenails that subsequently recurred. In this context, recommendations for clinical practice are proposed to contribute to the development of both effective treatment methods and preventive strategies. Materials and Methods: This retrospective study included 42 patients previously treated for ingrown toenails who developed recurrences due to various reasons. Patients with post-treatment complications (e.g., infection and bleeding), pain associated with the treatment, or dissatisfaction with the treatment were not considered as a recurrence and were excluded from the study. All patients gave informed consent for participation in the study. The demographic characteristics such as age and gender, patient-related factors that might affect recurrence (foot hygiene, footwear usage, nail trimming, additional deformities, trauma history, comorbidities), the clinics where the initial treatment was performed, and the initial treatment methods were recorded. Results: The mean age of the patients was 26.8 ± 10.1 years, with the youngest being 12.0 years and the oldest 49.0 years. Of the patients, 33.3% (n=14) were female, and 66.7% (n=28) were male. Comorbidities included diabetes mellitus in 21.4% (n=9), obesity in 31.0% (n=13), peripheral arterial disease in 7.1% (n=3), and hyperhidrosis in 16.7% (n=7). No predisposing factors were identified in 11.9% (n=5) of the 42 patients. An evaluation of initial treatment methods revealed that 40.5% (n=17) of the patients underwent Orthonyxia, 21.4% (n=9) underwent Chemical Partial Matricectomy, 21.4% (n=9) underwent Spicule Excision, and 16.7% (n=7) underwent Partial Matricectomy. Conclusion: Ingrown toenails are common in the general population and can significantly impair quality of life. When left untreated or improperly treated, they may result in unexpected and troublesome outcomes. Reducing risk factors and receiving appropria…
subject: Original Articles
  topic: section
subject: Ingrown toenail
  topic: keywords
subject: Recurrence
  topic: keywords
subject: Index treatment
  topic: keywords
subject: Partial matricectomy
  topic: keywords
subject: Nail trimming
  topic: keywords
creator: Mumin Karahan
creator: Mehmet Sah Sakci
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-09-25
publication date: 2025-09-25
starting page: 389
ending page: 393

Determination of density ranges to be used in grading hepatosteatosis using computed tomography
type: item
description: Aim: To determine the density ranges to evaluate the degree of hepatosteatosis on computed tomography (CT) grades. Materials and Methods: Patients who were diagnosed with hepatosteatosis by ultrasonography and those who subsequently underwent tomography were included in the study. Measurements were made from each segment of the liver and the spleen in the CT images of the graded groups. Liver/spleen density ratios were compared. Results: In total 666 patients were included for evaluation in the present study. Liver/spleen density ratios for Grade 1, Grade 2, and Grade 3 were 0.94 ± 0.19, 0.70 ± 0.16, and 0.37 ± 0.13, respectively. There was a statistically significant difference in the Liver/spleen density ratios throughout all grades (p=.001). The cut-off value separating Grade 1 and Grade 2 was calculated as 0.77, and the cut-off value separating Grade 2 and Grade 3 was calculated as 0.47. Segment 1, which had the least fat accumulation, was significantly different from all the other segments. Conclusion: In the present study, it was determined that both contrast-enhanced and non-contrast-enhanced tomography can be used for the evaluation of hepatosteatosis. However, contrast-enhanced tomography has been found to distinguish Grade 1 from Grade 2 more effectively than unenhanced CT.
subject: Original Articles
  topic: section
subject: Hepatosteatosis
  topic: keywords
subject: Density range
  topic: keywords
subject: Computed tomography
  topic: keywords
subject: Ultrasonography
  topic: keywords
creator: Gulhan Kilicarslan
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-09-25
publication date: 2025-09-25
starting page: 394
ending page: 400

A novel benzamide derivative SY-15 inhibits multiple myeloma cell proliferation
type: item
description: Aim: Over the past two decades, the natural course of multiple myeloma (MM) has changed significantly, primarily due to the emergence of novel therapeutic agents targeting the bone marrow microenvironment (BMM). Despite these advancements, the underlying mechanisms of drug resistance remain largely unclear. In this study, the effects of a novel benzamide derivative, SY-15, on MM cell lines were investigated, and the findings suggest that this molecule could be a promising anticancer drug candidate, warranting further research. Materials and Methods: Multiple myeloma (MM) cell lines (MM1S, U266, H929, RPMI8226) were cultured, and the effects of various concentrations of a novel benzamide derivative on cell viability were evaluated using the MTT assay. Results: The anticancer activity of the SY-15 molecule was evaluated in multiple myeloma (MM) cell lines following 72 hours of treatment, and for comparison, in the L929 normal fibroblast cell line. A statistically significant difference in cell viability percentages was observed among the five cell lines (p<0.001). The median cell viability percentage was 93.6247 for the L929 cell line, 44.4110 for the MM1S cell line, 22.4655 for H929, 31.7180 for U266, and the lowest median value was recorded in the RPMI 8226 cell line at 13.0931. Notably, SY-15 did not exhibit significant cytotoxicity in L929 fibroblast cells. Conclusion: SY-15 has the potential to be an effective anticancer agent with high selectivity and low toxicity for the treatment of MM. It may offer a novel therapeutic option, particularly for patients who have developed resistance to other MM drugs.
subject: Original Articles
  topic: section
subject: Multiple myeloma
  topic: keywords
subject: SY-15 molecule
  topic: keywords
subject: Anticancer drug
  topic: keywords
creator: Nigar Abdullayeva
creator: Kubra Gayret
creator: Nazila Farhangzad
creator: Ebru Dumlupinar
creator: Serap Yilmaz Ozguven
creator: Asuman Sunguroglu
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-10-24
publication date: 2025-10-24
starting page: 421
ending page: 428

Intersphincteric anal abscess, a rare cause of axial low back pain: A case report
type: item
description: A 60-year-old male patient presented with axial lower back pain. He had suffered from pain for one month. Within a week, the patient's pain had increased, and he experienced additional symptoms of fever, malaise, and weight loss. Lumbar MRI revealed an intersphincteric anal abscess extending to the level of the lower lumbar vertebrae. The patient was then referred to a general surgeon. After drainage of the abscess and administration of broad-spectrum antibiotics, the patient's pain resolved within one week. This case report describes a rare presentation of lower back pain, in which a normal physical examination led to an initial delay in considering an anal abscess. The diagnosis of an advanced intersphincteric abscess was ultimately established by a lumbar MRI, which had been ordered to investigate for possible malignant metastasis.
subject: Case Reports
  topic: section
subject: Anal abscess
  topic: keywords
subject: Low back pain
  topic: keywords
subject: Analgesia
  topic: keywords
creator: Ezgi Can
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-08-25
publication date: 2025-08-25
starting page: 375
ending page: 377

Rim enhancement, drainage, and inflammatory response in patients with anterior versus posterior lingual abscesses
type: item
description: Aim: Lingual abscesses are rare but potentially serious infections of the tongue, with limited data available in the literature. This study aimed to compare the clinical, radiological, and laboratory features of anterior and posterior lingual abscesses and evaluate the impact of drainage on patient outcomes. Materials and Methods: This retrospective case series included 17 patients diagnosed with lingual abscess between February 2019 and March 2025. Patients were categorized based on anatomical localization (anterior vs. posterior). Demographic data, symptoms, laboratory values (WBC, CRP, etc), computed tomography findings, treatment modalities, and outcomes were analyzed. Subgroup comparisons were performed based on abscess location, drainage status, and rim enhancement. Results: Of the 17 patients, 10 had anterior and 7 had posterior abscesses. Posterior abscesses were larger and associated with significantly longer hospital stays (p = 0.004). Drainage was associated with significantly shorter hospitalization (p = 0.005) and greater reduction in white blood cell counts by day 5 (p = 0.046). Rim enhancement on computed tomography was not significantly associated with clinical or laboratory outcomes. Streptococcus species were the most commonly isolated pathogens. No major complications or airway interventions were required. Conclusion: Posterior lingual abscesses demonstrate a more severe clinical course than anterior abscesses. Surgical drainage is associated with improved inflammatory markers and faster clinical recovery. Rim enhancement alone may not reliably reflect disease severity. These findings support the importance of early diagnosis and individualized management based on anatomical location and clinical progression.
subject: Original Articles
  topic: section
subject: Tongue disease
  topic: keywords
subject: Abscess
  topic: keywords
subject: Drainage
  topic: keywords
subject: Mediators of inflammation
  topic: keywords
creator: Kadir Sinasi Bulut
creator: Fatih Gul
creator: Ali Ozturk
creator: Tuba Saadet Deveci Bulut
creator: Burak Celik
creator: Serkan Serifler
creator: Mehmet Ali Babademez
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-11-25
publication date: 2025-11-25
starting page: 486
ending page: 492

Functional neurological (conversion) symptoms mediate the effect of self-stigma in women seeking psychological help on their psychological well-being
type: item
description: Aim: This study aimed to examine the effect of self-stigma of seeking psychological help on psychological well-being in patients diagnosed with functional neurological symptom disorder (formerly conversion disorder) through conversion symptoms. Materials and Methods: In this cross-sectional study, the Self-Stigma of Seeking Psychological Help Scale (SSPHS), Psychological Well-Being Scale (PWBS), and Somatoform Dissociation Questionnaire (SDQ-20) were administered to the FNSD and HC groups. Results: The FNSD group consisting of 31 females (12 motor (M)-FNSD, 9 somatosensory (SS)-FNSD, and 10 mixed-FNSD) and the HC group consisting of 32 females were similar in terms of age (p = 0.350), education level (p = 0.386), marital status (p = 0.579), and working status (p = 0.136). Significant differences were observed between the FNSD and HC groups in terms of SSPHS (p<0.001), PWBS (p<0.001), and SDQ-20 (p<0.001). Significant differences were observed between the M-FNSD, SS-FNSD, and Mix-FNSD subgroups in terms of SDQ-20 (p = 0.034), SSPHS (p = 0.028), and PWBS (p = 0.015). The comparison that caused significant differences in terms of SDQ-20, SSPHS, and PWBS scores among the FNSD subgroups was between M-FNSD and Mix-FNSD. The mediating role of the FNSD symptom level (SDQ-20) in the relationship between SPH and PW was examined. The indirect effect of SPH on PW was determined as -0.436 (49.65%). The direct effect of SPH on PW was determined as -0.442 (50.35%). In the correlation analysis performed in the FNSD group, a significant relationship was found between SSPHS and SDQ-20 (r=0.921, p<0.001), between SSPHS and PWBS (r=-0.879, p<0.001), and between PWBS and SDQ-20 (r=-0.882, p<0.001). Conclusion: This study demonstrates that SPH increases and PW decreases in FNSD and that FNSD symptoms mediate the relationship between SPH and PW.
subject: Original Articles
  topic: section
subject: Functional neurological symptom disorder
  topic: keywords
subject: Conversion disorder
  topic: keywords
subject: Psychological well-being
  topic: keywords
subject: Self-stigma
  topic: keywords
subject: Mediation analysis
  topic: keywords
creator: Dilek Orum
creator: Murad Atmaca
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-09-25
publication date: 2025-09-25
starting page: 401
ending page: 407

Comparison of patients undergoing general anesthesia or ultrasonography-guided interscalene block in shoulder surgery in terms of postoperative analgesia: A retrospective study
type: item
description: Aim: We aimed to evaluate the pain scores with visual analog scale and compare opioid consumption in the early postoperative period in cases where single-shote interscalene brachial plexus block and general anesthesia or general anesthesia alone have been applied for arthroscopic shoulder surgery. Materials and Methods: Seventy-one patients, aged 18-65, who had undergone elective arthroscopic shoulder surgery were included in this study. Participants were allocated to one of two groups: the General Anesthesia (GA) group (n=36) or the Interscalene Block and General Anesthesia (ISBPB+GA) group (n=35). The severity of postoperative pain was evaluated using Visual Analog Scale (VAS) scores. Results: The VAS scores and analgesic requirements of patients in the ISBPB+GA group were significantly lower than GA group. Although the duration of operation was shorter in the ISBPB+GA group (87.37±17.65 min), it did not reach statistical significance (p˃0.05). Surgeon and patient satisfaction scores were higher in the ISBPB+GA group compared to patients who underwent GA alone. Conclusion: The cases that underwent ISBPB+GA had notably lower pain scores and decreased additional analgesic consumption in the postoperative period. We believe that this anesthesia technique provides a more comfortable recovery process in patients undergoing shoulder surgery and can be safely utilized by experienced anesthesiologists.
subject: Original Articles
  topic: section
subject: Interscalene block
  topic: keywords
subject: Shoulder surgery
  topic: keywords
subject: Postoperative analgesia
  topic: keywords
creator: Onur Hanbeyoglu
creator: Ayse Azak Bozan
creator: Gokhan Urhan
creator: Umit Karatepe
creator: Oguz Kaya
creator: Omer Cihan Batur
creator: Mustafa Umit Gurbuz
creator: Aykut Urfalioglu
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-08-25
publication date: 2025-08-25
starting page: 362
ending page: 367

An increase in neuropathic complaints corresponds to the severity of central sensitization-related symptoms in women with fibromyalgia: A cross-sectional study
type: item
description: Aim: This study aimed to investigate the relationship between central sensitization (CS)-related symptoms and neuropathic complaints in female patients with fibromyalgia (FM). Materials and Methods: Demographic and clinical variables, including disease duration, current medication, severity of pain, and the FM survey questionnaire, were all recorded. The Fibromyalgia Impact Questionnaire (FIQ) was used to assess the severity of the FM. Neuropathic complaints were investigated by the Self-Leeds Assessment of Neuropathic Symptoms and Sign (S-LANSS) and CS-related symptoms by the Central Sensitization Inventory (CSI), and patient data were compared according to the CSI severity levels. Patients with CSI scores that are at least moderate (CSI≥40) were considered to have central sensitization syndrome (CSS). Results: One hundred and forty female FM patients were included in the study. The mean (SD) S-LANSS score was calculated as 15.06 (5.61) for all patients. A total of 135 patients (96.4%) had CSS; the mean (SD) CSI-A score for all patients was 61.39 (13.03). Of them, 81.4% (n = 114) were in the very severe CSS group. There was an increase in pain intensity, FIQ, and S-LANSS scores in parallel with the severity of CS-related symptoms (p<0.001). CS-related symptoms and disease severity were shown to have significant effects on S-LANSS variation in hierarchical regression analysis (β:0.34, CI:0.08-0.26, p<0.001; β:0.25, CI:0.01-0.20, p=0.035, respectively). Conclusion: Neuropathic complaints become evident in tandem with the severity of CS-related symptoms in female FM patients. Clarifying its potential association to CS-related symptoms may help clinicians to understand neuropathic complaints in FM patients in more detail.
subject: Original Articles
  topic: section
subject: Central nervous system
  topic: keywords
subject: Central nervous system sensitization
  topic: keywords
subject: Chronic pain
  topic: keywords
subject: Fibromyalgia
  topic: keywords
creator: Feyza Nur Yücel
creator: Sefa Kurt
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-08-25
publication date: 2025-08-25
starting page: 335
ending page: 343

Examining the relationship between sustainability consciousness and physical activity in healthy young adults
type: item
description: Aim: Sustainability consciousness (SC) refers to the awareness and lived experience of sustainability phenomena, which includes personal insights and viewpoints. The objective of this study is to assess the correlation between SC and physical activity among young, healthy volunteers. Materials and Methods: We assessed sustainability consciousness (SC) using the Sustainability Consciousness Questionnaire (SCQ) and physical activity levels with the International Physical Activity Short Form (IPAQ-sf). Results: We included 235 participants in the study, with ages ranging from 18 to 33 years and an average BMI of 23.01. The study found no statistically significant association between overall physical activity levels (IPAQ-SF) and overall sustainability consciousness (SCQ) (p > .05). Furthermore, none of the IPAQ-SF sub-parameters showed a significant correlation with the SCQ's total scores for knowledge (r=-.014, p=.835), attitude (r=-.007, p=.912), or behavior (r=.070, p=.287). When examining the SCQ sub-parameters, we found no significant association between knowledge (economic) and attitude (environment) (r=-.040, p=.539), or between knowledge (economic) and behavior (social) (r=-.047, p=.472). However, all other SCQ sub-parameters showed significant intercorrelations (p<.001). Specifically, knowledge (social) and behavior (social) sub-parameters were not significantly related (r=.026, p=.689), but all other pairings within the SCQ sub-parameters were significantly correlated (p<.001). Conclusion: This study found no association between sustainability consciousness (SC) and physical activity in healthy young individuals. However, we did observe significant interrelationships among the knowledge, attitude, and behavior sub-parameters of the Sustainability Consciousness Questionnaire (SCQ), across economic, social, and environmental dimensions.
subject: Original Articles
  topic: section
subject: Consciousness
  topic: keywords
subject: Sustainability development
  topic: keywords
subject: Healthy volunteers
  topic: keywords
subject: Higher education
  topic: keywords
subject: Sustainability knowledge
  topic: keywords
creator: Fatma Nur Takı
creator: Musa Çankaya
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-08-25
publication date: 2025-08-25
starting page: 355
ending page: 361

Investigation of the prognostic impact of proline-rich protein 11 (PRR11) transcription levels in early-stage bladder cancer
type: item
description: Aim: To investigate proline-rich protein 11 (PRR11) transcription levels and its prognostic effect in early-stage (non-metastatic) bladder cancer. Materials and Methods: Thirty-one patients diagnosed with early-stage (non-metastatic) bladder cancer were included in the study. Tumor tissues of the patients at the time of diagnosis were obtained from the pathology laboratory, PRR11 transcription levels were analyzed, and "median fold change" values ​​for PRR11 transcription levels were obtained. According to the median PRR11 transcription level determined from these values, the patients were divided into two groups (n = 16 and n = 15). The demographic and clinicopathological characteristics of the patients were examined, and the survival outcomes of the two groups were compared. Results: The determined median PRR11 transcription level was 1.386 (range: 0.135- 2.016). In the patient group with a median PRR11 transcription level ≤1.381 (n=16), median disease-free survival (mDFS) was 19 months (95% CI: 2.1-48.4 months); in the group with >1.381 (n=15), mDFS was 11 months (95% CI: 7.5-14.4 months). In the group with ≤1.381, median overall survival (mOS) was 27 months (95% CI: 4.1-58.3 months), and in the group with >1.381, mOS was 14 months (95% CI: 8.1-19.8 months). Conclusion: Our study revealed a negative correlation between PRR11 transcription level and survival outcomes in patients with early-stage bladder cancer. The PRR11 transcription level may be a prognostic marker in patients with early-stage bladder cancer. More comprehensive, prospective, and randomized controlled trials are needed.
subject: Original Articles
  topic: section
subject: Biomarker
  topic: keywords
subject: Bladder cancer
  topic: keywords
subject: Prognosis
  topic: keywords
subject: Proline-rich protein 11
  topic: keywords
creator: Alper Turkel
creator: Mutlu Dogan
creator: Nazan Bozdogan
creator: Haktan Bagis Erdem
creator: Cengiz Karacin
creator: Sultan Cigdem Irkkan
creator: Taha Bahsi
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-08-25
publication date: 2025-08-25
starting page: 350
ending page: 354

Evaluation of clinical and demographic characteristics of elderly patients receiving inpatient treatment in a university hospital psychiatry clinic
type: item
description: Aim: In this study, we aimed to examine the sociodemographic and clinical characteristics of geriatric patients receiving inpatient treatment in the psychiatry clinic of a university hospital. Materials and Methods: This retrospective study was conducted by examining the medical records of patients aged 65 and over who received psychiatric treatment between January 1, 2018 and December 31, 2023. Data related to the patients were obtained from the electronic patient database of the hospital. Results: A total of 252 patients, consisting of 124 females and 128 males, were included in the study. The mean age of the patients was 70.67 ± 5.01 years, and the average length of hospital stay was 17.35 ± 12.18 days. The diagnoses were, respectively, anxiety disorder (46.8%), depression (25.0%), mood disorder (10.7%), psychotic disorders (8.3%), alcohol/substance dependence (2.0%), psychiatric disorders related to general medical conditions (4.8%), dementia (1.2%), and intellectual disability (0.4%). In total, 22.8% had received inpatient treatment more than once. The condition that most often caused repeated hospitalizations was anxiety disorder, and 39% of these patients had a coexisting chronic disease. Depression was the most common mental disorder accompanying anxiety (15.3%). Mild or higher dementia was detected in 24 of 64 patients who underwent Mini-Mental State Examination. While the rates of comorbid chronic diseases were high in patients with Yeşil Kart (s form of preliminary social security), the rate of female patients hospitalized due to psychotic disorders was higher than that of males Conclusion: Determining the frequency of psychiatric disorders in hospitalized elderly patients and knowing the characteristics that case repeated hospitalization will contribute to the planning and development of appropriate treatment strategies.
subject: Original Articles
  topic: section
subject: Old age
  topic: keywords
subject: Psychiatry
  topic: keywords
subject: Demographic characteristics
  topic: keywords
subject: Repeated hospitalization
  topic: keywords
creator: Abdurrahim Bakirhan
creator: Neslihan Cansel
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-08-25
publication date: 2025-08-25
starting page: 328
ending page: 334

Efficacy of therapeutic plasma exchange in HELLP syndrome: A single-center experience
type: item
description: Aim: The objective of this study is to investigate the clinical efficacy of therapeutic plasma exchange in HELLP (Hemolysis, Elevated Liver Enzyme, Low Platelet) syndrome and its contribution to renal failure, which is an independent risk factor for maternal mortality. Materials and Methods: From 2019 to 2024, 20 patients diagnosed with HELLP syndrome who underwent therapeutic plasma exchange (TPE) were included. We evaluated the patients' pre- and post-procedure values to determine the efficacy of the procedure. Results: The median age of patients was 30 (19-38) years, and the median number of days of TPE was 6 days (3-14). There was a statistically significant increase in hemoglobin and platelet values and a statistically significant decrease in lactate dehydrogenase, total bilirubin, direct bilirubin, aspartate aminotransferase, alanine aminotransferase, urea, and creatinine values. The number of TPE sessions, length of stay in hospital, and the length of intensive care unit stay were significantly higher in hemodialysis patients. Conclusion: TPE is an effective treatment modality for both clinical improvement and prevention of permanent renal failure in patients with persistent postpartum hemolysis who are followed for HELLP syndrome.
subject: Original Articles
  topic: section
subject: HELLP syndrome
  topic: keywords
subject: Therapeutic plasma exchange
  topic: keywords
subject: Renal failure
  topic: keywords
creator: Kubra Oral
creator: Ayse Uysal
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-09-25
publication date: 2025-09-25
starting page: 378
ending page: 382

The effect of music to sleep quality on liver transplanted patients
type: item
description: Aim: This study aimed to evaluate the effect of music listening on sleep quality in adult liver transplant recipients. Given the limited research in this specific patient population, the study contributes to the growing body of evidence supporting non-pharmacological strategies in postoperative nursing care. Materials and Methods: A quasi-experimental pre-test/post-test control group design was employed. A total of 88 patients were included, with 44 assigned to the experimental group and 44 to the control group. Sleep quality was assessed using the Richards-Campbell Sleep Questionnaire (RCSQ) before and after the intervention. The experimental group listened to 30 minutes of culturally familiar music each night for four consecutive days, while the control group received standard care only. Results: Baseline RCSQ scores indicated poor sleep quality in both groups. Following the intervention, the experimental group showed a statistically significant improvement in total RCSQ scores (from 24.0 to 50.0, p < 0.001). Subscale analysis revealed significant improvements in all five RCSQ dimensions—sleep depth, sleep latency, frequency of nighttime awakenings, wake time, and overall sleep quality (p < 0.001). In contrast, the control group showed no meaningful change except for a slight improvement in the frequency of awakenings subscale (p = 0.035). Conclusion: These findings suggest that music listening can significantly enhance sleep quality in liver transplant recipients. As a safe, inexpensive, and easy-to-apply method, music listening holds promise for integration into routine postoperative nursing care to promote patient comfort and recovery.
subject: Original Articles
  topic: section
subject: Liver transplantation
  topic: keywords
subject: Music
  topic: keywords
subject: Sleep quality
  topic: keywords
subject: Postoperative care
  topic: keywords
subject: Nursing intervention
  topic: keywords
subject: Richards-Campbell Sleep Questionnaire
  topic: keywords
creator: Hasan Saritas
creator: Meral Ozkan
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-08-25
publication date: 2025-08-25
starting page: 368
ending page: 374

Analysis of intestinal parasitic infections seen in the Southeastern Anatolia Region tertiary hospital between 2019-2024
type: item
description: Aim: The objective of this study was to determine the prevalence of intestinal parasites over time among patients who presented with dyspeptic complaints and sought stool samples from a Turkish tertiary hospital, and to investigate the correlation between intestinal parasites and age and gender. Material and Methods: A retrospective study was conducted between 2019 and 2024 at Siirt Education and Research Hospital to determine the intestinal parasites (IP) trend. We assessed the association between IP and age and gender groupings, as well as the distribution of IP types by year. Stool samples were analyzed using the nativ-lugol technique under a direct light microscope. All data lacking sociodemographic characteristics and the year of stool examination were excluded from the study. Results: Data from 6291 patients were analyzed. In total, 56.9% of the patients were male. The presence of parasites in accord with the gender did not differ significantly (p=0.528). The prevalence of parasites was 5.7% in the 18–65 age group and 9.0% in the over-65 age group(p=0.006). The most common IP species were E. histolytica (48.3%), B. hominis (28.2%), and G. intestinalis (22.5%, n=84). The incidence of H. nana (1.1%, n=4) was very low. Conclusion: IP is a serious threat to health, particularly in developing countries. The prevalence of IP will decrease as our awareness increases together with efficient diagnosis, treatment, and prevention strategies.
subject: Original Articles
  topic: section
subject: Intestinal parasites
  topic: keywords
subject: Trend analysis
  topic: keywords
subject: Turkey
  topic: keywords
creator: Ali Karabulut
creator: Leyla Gunduz
rights: Copyright (c) 2025 Annals of Medical Research https://creativecommons.org/licenses/by-nc-nd/4.0
date: 2025-08-25
publication date: 2025-08-25
starting page: 344
ending page: 349