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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

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Autoimmune polyglandular syndrome type III which accompanies to multiple sclerosis: A case report (p. 3053-7)

Autoimmune polyglandular syndrome type III which accompanies to multiple sclerosis: A case report (p. 3053-7)

Ahmet Gorgel1, Mehmet Tecellioglu2, Cem Cankaya3
1Gozde Akademi Hospital, Clinic of Endocrinology and Metabolism, Malatya, Turkey
2Inonu University, Faculty of Medicine, Department of Neurology, Malatya, Turkey
3Inonu University, Faculty of Medicine, Department of Ophthalmology, Malatya, Turkey

Abstract

Autoimmune polyglandular syndrome type III (APS III) is characterised by autoimmune destruction of various endocrine and non-endocrine tissues. It differs from APS I and APS II in terms of without adrenal involvement. Although APS III includes a series of autoimmune disorders, it is rarely associated with multiple sclerosis (MS). A 41-year-old female patient had diplopia, visual blurring, dizziness, and giddiness for 2 weeks. In her medical history, she had a diagnosis of MS and using Teriflunomide. It was detected positivity of antinuclear antibody (ANA), anti-thyroid peroxidase (Anti-TPO) and anti-thyroglobulin (Anti-TG) antibodies. Based on these results, the patient with MS who has chronic autoimmune thyroiditis and primary ovarian failure was diagnosed with APS III. The coexistence of APS-III and MS is a rare clinical entity. Moreover, hypothyroidism has been detected during teriflunomide therapy in the patient. Hypothyroidism was most likely a component of APS-III in our case, but it may also have been triggered by teriflunomide.

Keywords: Autoimmune polyglandular syndrome (APS) type III; multiple sclerosis; teriflunomide

 

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doi: 10.5455/annalsmedres.2019.07.420

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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