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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

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Botulinum toxin applications at doses appropriate for aesthetic procedures: Effect on tension type headache (p.484-9)

Botulinum toxin applications at doses appropriate for aesthetic procedures: Effect on tension type headache (p.484-9)

Aybala Neslihan Alagoz1, Can Ilker Demir2
1Kocaeli University Faculty of Medicine, Department of Neurology, Izmit, Turkey
2Kocaeli University Faculty of Medicine, Department of Plastic and Reconstructive Surgery, Izmit, Turkey
Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.


Aim: Prophylactic treatment options for tension-type headache are limited. Studies have demonstrated beneficial effects of botulinum toxin-A in headache suffers. This study aimed to evaluate the effect of application of Btx-A at normal aesthetic procedure doseage in the treatment of tension-type headache.
Material and Methods: Forty-six patients (37 females; 80.4%), were included in the study, sub-divided by type of head-ache; chronic or episodic. All patients received 55 UI botulinum toxin-A. Pain frequency and severi-ty were evaluated by neurological examination and visual analog scale, before application, three and six months after application. Results were compared at time points and between the groups.
Results: Mean±standard deviation age of the patients was 41.80±8.36 years. Episodic and chronic tension-type headache was present in 54.3% (n = 25) and 45.7% (n = 21), respectively. In both episodic and chronic tension-type headache there was a significant reduction in visual analog score score at both the third (p=0.001) and sixth (p=0.001) months post-application compared with preapplication. However, visual analog score scores significantly worsened by the sixth month compared to the third month (p=0.01 and p=0.007 for episodic and chronic tension-type headache, respectively) while remaining improved compared to baseline. In episodic tension-type headache, frequency of occurrence decreased significantly at the third (p=0.025) but not at the sixth (p=0.16) months com-pared to baseline. In chronic tension-type headache there was no difference in the frequency of ten-sion-type headache at any time point (p>0.05).
Conclusion: We believe that there may be a role for low dose botulinum toxin-A in the prophylactic treatment of tension-type headache but further larger studies are required to confirm this and identify the optimal dose.

Keywords: Botulinum toxin; headache; tension-type; treatment



doi: 10.5455/annalsmedres.2020.02.136



Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.


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