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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

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Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects (p.454-60)

Evaluation of specific heavy metal levels of pregnant women complicated by neural tube defects (p.454-60)

Talip Karacor1, Pinar Kirici1, Mehmet Can Nacar1, Mehmet Bulbul1, Muhittin Onderci2, Nurullah Peker3
1Adiyaman University, Faculty of Medicine, Department of Obstetrics and Gynecology, Adiyaman, Turkey
2Adiyaman University, Faculty of Medicine, Department of Biochemistry, Adiyaman, Turkey
3Dicle University, Faculty of Medicine, Department of Obstetrics and Gynecology, Diyarbakir, Turkey
Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.

Abstract

Aim: The etiology of neural tube defect (NTD) is still not clear enough. In our study, we aimed to evaluate plasma heavy metal levels of pregnant women with NTD and to determine whether there is a relationship between heavy metal levels and NTD severity.
Material and Methods: TThis study was conducted in Adıyaman University, Department of Gynaecology and Obstetrics. The study included 38 pregnant women with NTD and 42 pregnant women with healthy infants. Pregnant women who have NTD were divided into two groups as NTD Type 1 and NTD Type 2 according to the anomaly type. Levels of heavy metals such as Mercury (Hg), Cadmium (Cd), Cobalt (Co), Lead (Pb), Manganese (Mn) and Arsenic (As) were compared between groups.
Results: Plasma Hg, Co, Cd and Pb levels were higher in NTD group than control group. (p values, respectively; p 0.001, p = 0.001, p 0.001, p 0.001). As and Mn levels were not statistically different between the two groups (p values; p = .519, p = .819, respectively). In the NTD group, Hg was found to be higher in NTD Type 1 than NTD Type 2 (p 0.001).
Conclusion: It is obvious that some histomorphological changes are formed in the cardinal ligaments of patients with uterine prolapse due to pressure on the uterus. We believe that the increase in the number of extravasated erythrocytes and the thickness of the vascular wall and peripheral nerve should be supported by further studies.

Keywords: Anencephaly; heavy metal; neural tube defect; pregnancy; spina bifida

 

 

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doi: 10.5455/annalsmedres.2019.12.889

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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