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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

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Presence of a genetic association between  NRG-3 SNP rs17101193 and schizophrenia (p.1329-32)

Presence of a genetic association between NRG-3 SNP rs17101193 and schizophrenia (p.1329-32)

Mustafa Mert Sozen1, Ceren Acar1, Sukru Kartalci2
1Inonu University, Faculty of Science and Literature, Department of Molecular Biology and Genetics, Malatya, Turkey
2Inonu University, Faculty of Medicine, Department of Psychiatry, Malatya, Turkey
Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.

Abstract

Aim: NRG-3 gene is a member of neuregulin signaling pathway and alleles of several single nucleotide polymorphisms (SNP) located in this gene are suspected to be associated with schizophrenia. During this work, we have done a study to investigate the potential association of the SNP rs17101193 of NRG-3 gene.
Material and Methods: We used the DNA samples from 301 unrelated schizophrenia patients and 326 healthy control samples collected from Malatya-Turkey to determine the SNP genotypes. After genotyping, we compared the genotypes and alleles in terms of distributions between cases and controls. We also applied the recessive models for both alleles to get a more clarified result. We used Chi-Squared test and Fisher’s exact test for hypothesis testing.
Results: Even though the difference between the case and control groups were not significant in context of distributions of two alleles of rs17101193, the distributions of genotypes were significantly different (p = 0.046). On the other hand, one of the genotypes (AA) was seen only in the patients.
Conclusion: The results of our analyses and statistical test indicated that rs17101193 SNP of NRG-3 gene has a potential to be associated with schizophrenia and homozygosity of “A” allele seems to be a risk factor in our population. More evidence from separate case-control studies from different populations may be required to strengthen this idea.

Keywords: Association; genetics; NRG3; polymorphism; schizophrenia; SNP

 

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doi: 10.5455/annalsmedres.2020.02.170       

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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