Seyhan Dikci1, Halil Keskin2
1Samsun Maternity and Children Hospital, Department of Ophthalmology, Samsun, Turkey
2Samsun Maternity and Children Hospital, Department of Pediatrics, Samsun, Turkey
Original Articles (8)
Seyhan Dikci1, Halil Keskin2
Bekir Serdar Ünlü1, Akif Acay2, Gülen Gül Köken1, Yunus Yıldız3, Elif Telciler1, Mine Kanat Pektaş1, Dağıstan Tolga Arıöz1, Mehmet Yılmazer1
1Kocatepe University School of Medicine, Department of Gynecology and Obstetrics, Afyonkarahisar, Turkey
2Kocatepe University School of Medicine, Department of Internal Medicine, Afyonkarahisar, Turkey
3Ilgın State Hospital, Gynecology and Obstetrics Clinic, Konya, Turkey
Measuring, Evaluating, and Mapping the Electromagnetic Field Levels in Turgut Ozal Medical Center Building and Environment (p. 186-95)
Teoman Karadağ1, Teymuraz Abbasov2, Müge Otlu Karadağ3
1Inonu University, Electrical and Electronics Engineering, Malatya, Turkey
2Inonu University, Electrical and Electronics Engineering, Malatya, Turkey
3Malatya State Hospital, Pulmonary Diseases Clinic, Malatya, Turkey
Demographic and Clinical Features of Migrain Headache of Women in Relation to Functional Disability (p. 196-201)
Ersin Kasım Ulusoy1, Turgay Albayrak2, İrfan Şencan2, Bilen Şule3, Haşimoğlu Abas2
1Develi State Hospital, Neurology Clinic, Kayseri, Turkey
2Ankara Numune Research and Training Hospital, Family Medicine Department, Ankara, Turkey
3Ankara Numune Research and Training Hospital, Neurology Clinic, Ankara, Turkey
Relationship of COX-2, BAX, BCL-2, Ki67, p53 Expression to Clinicopathologic Parameters and Their Impact on Prognosis in Renal Cell Carcinoma (p. 207-14)
Fatma Seher Pehlivan1, Ayşegül Sarı2, Sacit Nuri Görgel3, Yelda Morgül2, Uğur Balcı3, Murat Ermete2, Ertuğrul Şefik3
1Private Tınaztepe Hospital, Pathology Clinic, İzmir, Turkey
2Katip Celebi University, Training and Research Hospital, Pathology Clinic, İzmir, Turkey
3Katip Celebi University, Training and Research Hospital, 1st Urology Clinic, İzmir, Turkey
Objective: Renal cell carcinoma (RCC) is a malignancy originating from the renal cortex and is accounted for 85% of all malignant kidney tumors. Currently, tumor stage and nuclear grade are recognized as the most important determinants of prognosis in patients with RCC. Nonetheless, staging and grading do not suffice for predicting the prognosis in many patients. However, determining such patients bears importance in terms of oncology. Therefore, additional parameters are required to define the tumor behavior. In this study, we aimed to investigate the relation of Cox-2, Bax, Bcl-2, and p53 expression, as well as Ki-67 proliferation index to histopathologic parameters, and their impact on prognosis.
Material and Methods: Our study included 70 RCC patients who were referred to the Pathology Department of Izmir Ataturk Teaching and Research Hospital from the First Urology Clinic between May 1998 and May 2008. The data including tumor diameter, histologic tumor type, nuclear grade, tumor stage, metastatic status, life expectancy of patients as well as staining percentages of Bax, Cox-2, Bcl-2, p53, and Ki-67 were compared.
Results: In this study, no relationship was found between those markers and clinicopathologic parameters including the prognosis.
Conclusion: Tumor pathologic stage showed a statistically significant predictive value for metastasis development, however, it failed to predict survival. There is a need for studies including standardized methods, larger samples, and longer follow-up periods in order to reveal effects of Cox-2, Bax, Bcl-2, P53 markers, and Ki-67 proliferation index on prognosis.
Key Words: Renal Cell Carcinoma; Cox-2; Bax; Bcl-2; ki67; p53.
Serap Baydur Şahin1, Hacer Sezgin2, Teslime Ayaz3, Emine Uslu Gür3, Kadir İlkkılıç3, Ekrem Algün1
1Recep Tayyip Erdoğan University, School of Medicine, Department of Endocrinology and Metabolism, Rize, Turkey
2Recep Tayyip ErdoğanUniversity, School of Medicine, Department of Family Medicine, Rize, Turkey
3Recep Tayyip Erdoğan University, School of Medicine, Department of Internal Medicine, Rize, Turkey