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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

Current Issues

Original Articles (8)

The Role of Mean Platelet Volume in Preeclampsia (p. 181-5)

Bekir Serdar Ünlü1, Akif Acay2, Gülen Gül Köken1, Yunus Yıldız3, Elif Telciler1, Mine Kanat Pektaş1, Dağıstan Tolga Arıöz1, Mehmet Yılmazer1
1Kocatepe University School of Medicine, Department of Gynecology and Obstetrics, Afyonkarahisar, Turkey
2Kocatepe University School of Medicine, Department of Internal Medicine, Afyonkarahisar, Turkey
3Ilgın State Hospital, Gynecology and Obstetrics Clinic, Konya, Turkey

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Relationship of COX-2, BAX, BCL-2, Ki67, p53 Expression to Clinicopathologic Parameters and Their Impact on Prognosis in Renal Cell Carcinoma (p. 207-14)

Fatma Seher Pehlivan1, Ayşegül Sarı2, Sacit Nuri Görgel3, Yelda Morgül2, Uğur Balcı3, Murat Ermete2, Ertuğrul Şefik3
1Private Tınaztepe Hospital, Pathology Clinic, İzmir, Turkey
2Katip Celebi University, Training and Research Hospital, Pathology Clinic, İzmir, Turkey
3Katip Celebi University, Training and Research Hospital, 1st Urology Clinic, İzmir, Turkey

Abstract
Objective: Renal cell carcinoma (RCC) is a malignancy originating from the renal cortex and is accounted for 85% of all malignant kidney tumors. Currently, tumor stage and nuclear grade are recognized as the most important determinants of prognosis in patients with RCC. Nonetheless, staging and grading do not suffice for predicting the prognosis in many patients. However, determining such patients bears importance in terms of oncology. Therefore, additional parameters are required to define the tumor behavior. In this study, we aimed to investigate the relation of Cox-2, Bax, Bcl-2, and p53 expression, as well as Ki-67 proliferation index to histopathologic parameters, and their impact on prognosis.
Material and Methods: Our study included 70 RCC patients who were referred to the Pathology Department of Izmir Ataturk Teaching and Research Hospital from the First Urology Clinic between May 1998 and May 2008. The data including tumor diameter, histologic tumor type, nuclear grade, tumor stage, metastatic status, life expectancy of patients as well as staining percentages of Bax, Cox-2, Bcl-2, p53, and Ki-67 were compared.
Results: In this study, no relationship was found between those markers and clinicopathologic parameters including the prognosis.
Conclusion: Tumor pathologic stage showed a statistically significant predictive value for metastasis development, however, it failed to predict survival. There is a need for studies including standardized methods, larger samples, and longer follow-up periods in order to reveal effects of Cox-2, Bax, Bcl-2, P53 markers, and Ki-67 proliferation index on prognosis.

Key Words: Renal Cell Carcinoma; Cox-2; Bax; Bcl-2; ki67; p53.

 

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doi: 10.7247/jtomc.2013.870

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Screening Patients with Polycystic Ovary Syndrome for Cushing’s Syndrome (p. 215-9)

Serap Baydur Şahin1, Hacer Sezgin2, Teslime Ayaz3, Emine Uslu Gür3, Kadir İlkkılıç3, Ekrem Algün1
1Recep Tayyip Erdoğan University, School of Medicine, Department of Endocrinology and Metabolism, Rize, Turkey
2Recep Tayyip ErdoğanUniversity, School of Medicine, Department of Family Medicine, Rize, Turkey
3Recep Tayyip Erdoğan University, School of Medicine, Department of Internal Medicine, Rize, Turkey

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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