Effects of high dose vitamin C administration in Covid-19 patients

Authors

  • Fatih Simsek Department of Anesthesiology and Reanimation, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Hasan Yonca Department of Infectious Diseases and Clinical Microbiology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Irmak Tahmaz Department of Internal Medicine, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Umut Kara Department of Anesthesiology and Reanimation, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Ender Sir Department of Anesthesiology and Reanimation, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Sami Eksert Department of Anesthesiology and Reanimation, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Mehmet Emin Ince Department of Anesthesiology and Reanimation, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Serkan Senkal Department of Anesthesiology and Reanimation, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Ilker Ozdemirkan Department of Anesthesiology and Reanimation, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Ufuk Turan Department of Anesthesiology and Reanimation, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Umit Savascı Department of Infectious Diseases and Clinical Microbiology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Deniz Dogan Department of Pulmonology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Canturk Tasci Department of Pulmonology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Ertugrul Yazici Department of Infectious Diseases and Clinical Microbiology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Gulden Yilmaz Department of Infectious Diseases and Clinical Microbiology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey
  • Ahmet Cosar Department of Anesthesiology and Reanimation, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey

Keywords:

Ascorbic acid, coronavirus, kidney function tests, severe acute respiratory syndrome, pneumonia

Abstract

Aim: There is currently no pharmacotherapy with for the treatment of COVID-19. We aimed to investigate the effects of early and high-dose vitamin C (VC) therapy in hospitalized patients with COVID-19.
Materials and Methods: We included patients (n=139) who received high-dose VC supplement to the standard treatment protocol into group 1 (n=58), and only those who received a standard treatment protocol into group 2 (n=81). The patients' requirement for supplemental oxygen therapy, requirement for intensive care treatment and survival rates was investigated retrospectively. Furthermore, the changes in white blood cell, C-reactive protein (CRP), procalcitonin, D-Dimer, renal function tests, ferritin, and interleukin 6 values during hospitalization were evaluated.
Results: When the groups were compared in terms of clinical data, there was no significant difference in terms of the patients requiring supplemental oxygen therapy (p=0.808), requiring intensive care (p=0.662), and survival rates (p=0.185). However, a significant difference was observed between the groups in terms of changes in renal function tests, and CRP values (p<0.05).
Conclusion: In the present study, early administration of high-dose VC to patients with COVID-19 has a reducing effect on the impaired kidney functions. Therefore, we recommend the use of VC as an early supplemental therapy in patients with COVID-19.

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Published

2021-09-27

How to Cite

Simsek, F., Yonca, H., Tahmaz, I., Kara, U., Sir, E., Eksert, S., Ince, M. E., Senkal, S., Ozdemirkan, I., Turan, U., Savascı, U., Dogan, D., Tasci, C., Yazici, E., Yilmaz, G., & Cosar, A. (2021). Effects of high dose vitamin C administration in Covid-19 patients. Annals of Medical Research, 28(9), 1699–1703. Retrieved from https://www.annalsmedres.org/index.php/aomr/article/view/3910

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