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Formerly Journal of Turgut Ozal Medical Center - ISSN 1300-1744

  • Annals of Medical Research



    Annals of Medical Research International Monthly Published Medical Journal

  • Annals of Medical Research

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  • Annals of Medical Research


    Annals of Medical Research indexed in TÜBİTAK/ULAKBİM Tıp Veri Tabanı

  • Annals of Medical Research


    Annals of Medical Research indexed in

  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research
  • Annals of Medical Research

Dear readers,

Our journal is the official publication of Inonu University Medical Faculty and published uninterruptedly for 25 years. It was first published as the name of Inonu University Medical Journal and later as Journal of Turgut Ozal Medical Center. During its publication period, the journal accepted Turkish or English articles for publication.

Abstracting in an international index is just a paramount objective in the 25th year of the journal. Because of this goal, it was necessary to make a decision both in terms of journal name and publication language. It was important in this respect that the name of a general medical journal should be related to medicine again and it should be in English. For these reasons, the name of the journal was switched to Annals of Medical Research and its publication language is changed to in English. The logo of the journal was chosen as an apricot, which is the symbol of our city Malatya, the world capital of apricot. I hope the journal succeeds with its new name. Annals of Medical Research is It is published monthly.

Editor-in-Chief
Cuneyt Kayaalp

 

Can monocyte to HDL ratio be used as an inflammatory marker in children with familial mediterranean fever? (p. 1453-7)

Can monocyte to HDL ratio be used as an inflammatory marker in children with familial mediterranean fever? (p. 1453-7)

Hatice Gunes1, Fatma Duksal2, Mesut Parlak3
1Kahramanmaras Sutçuimam University, Faculty of Medicine, Department of Pediatrics, Kahramanmaras Turkey
2sivas Numune Training And Research Hospital, Clinic of Pediatric Allergy and Immunology, Sivas, Turkey
3Sivas Numune Training And Research Hospital, Clinic of Pharmacology, Sivas, Turkey

Abstract

Aim: Familial Mediterranean fever (FMF); is an auto-inflammatory disease characterized by recurrent fever attacks. Inflammation continues even in the attack-free period. Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) is an inflammatory marker that has recently begun to use. The aim of the study was to evaluate the relationship between MHR and FMF in children.
Material and Methods: Sixty-two children with FMF in the attack-free period and 60-age and sex-matched- healthy controls included in the study. Patients divided into subgroups according to their gene mutation type. Monocyte count and HDL-C levels retrieved from medical records of patients and MHR were calculated from these data.
Results: The MHR of individuals were close to each other and there was no statistically significant difference between them ( p>0.05). Twenty-four of the patients had heterozygous, 4 had homozygous, 11 had a compound and 21 had negative mutations. Two of the patients had no mutation analysis. There was no significant difference between these four groups according to MHR (p=0.348). However, MHR revealed a positive correlation with fibrinogen (r=0.604, p0.005, n=24), serum amyloid A (r=0.437, p=0.005, n=39), C-reactive protein (r=0.277, p=0.005, n=101), and erythrocyte sedimentation rate (r=0.404, p0.001, n=104).
Conclusion: As a result, we showed MHR was not different from healthy controls in FMF patients. Contrary to what is claimed, the use of MHR as an inflammatory marker in FMF is doubtful.
Keywords: Monocyte hdl ratio; familial mediterranean fever; inflammation marker.

 

 

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doi: 10.5455/annalsmedres.2019.05.249

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Annals of Medical Research is the scientific official journal of the Inonu University Faculty of Medicine. It is published monthly. The essential aim of the Annals of Medical Research is to publish scientifically high quality clinical and experimental research articles on fields of medicine which can contribute to the literature data. In addition, review articles, case reports, editorials, letters to the editors and manuscripts on publication ethics and medical history, which can contribute to the education and practices of physicians and health sector professionals within the scope of the journal’s target audience and which can increase the level of scientific communication between the authors and readers, are included in the scope of the journal.

 

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