Effects of bosentan, sildenafil and their combination on T-wave amplitude and QT ınterval in a rat model of pulmonary hypertension

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Published: May 25, 2021

Keywords:

s: Pulmonary Arterial Hypertension Rat Model Sildenafil Bosentan Electrocardiography Echocardiography.

Derya Karpuz

Olgu Hallioglu

Belgin Buyukakilli

Serkan Gurgul

Bahar Tasdelen

Abstract

Aim: Although, bosentan and sildenafil have been used to treat PAH, the effect of these drugs on electrocardiographic (ECG) changes are still unclear. The aim of this study is to evaluate the effects of bosentan, sildenafil, and their combination on T-wave amplitude and QT interval in rats with monocrotaline (MCT)-induced PAH.

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How to Cite

Karpuz, D., Hallioglu, O., Buyukakilli, B., Gurgul, S., & Tasdelen, B. (2021). Effects of bosentan, sildenafil and their combination on T-wave amplitude and QT ınterval in a rat model of pulmonary hypertension . Annals of Medical Research, 24(1), 0037–0043. Retrieved from http://www.annalsmedres.org/index.php/aomr/article/view/2158