The association between CGRP gene -624 T→C polymorphism and headache severity in Turkish migraine patients

Abstract

Aim: This study aims to explore -624 T→C polymorphism on CGRP gene in migraine patients, and the relation between this polymorphism and migraine attacks.

Materials and Methods: The study registered a total of 101 migraine patients, 17 with aura and 84 without aura and 80 healthy volunteers. CGRP -624 T→C polymorphism in migraine patients and the control group was evaluated using PCR-RFLP method.

Results: Although no significant difference could be found between genotype and allele frequencies of CGRP -624T→C polymorphism in the patient and control groups (p>0.05). In addition, a statistically significant positive correlation was established between the severity of headache and C allele of this gene in migraine patients (p<0.05).

Conclusion: The fact that C allele of CGRP gene is at a higher rate in those with severe migraine attacks suggests that this allele can render neuroinflammation more marked by increasing the amount of CGRP. However, how CGRP -624T→C polymorphism influences the expressian level of the gene is not known for sure yet.