In-vitro evaluation of the effects of tigecycline on annulus fibrosus and nucleus pulposus | Annals of Medical Research

Annals of Medical Research

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Published: May 25, 2021

Keywords:

Chondroadherin gene cartilage oligomatrix protein interleukin-1beta intervertebral disc cell culture matrix metalloproteinase tigecycline

Yasin Emre Kaya

Ibrahim Yilmaz

Numan Karaarslan

Bulent Bilir

Duygu Yasar Sirin

Hanefi Ozbek

Abstract

Aim: This study aimed to examine the effects of tigecycline on primary cell cultures established using intervertebral disc tissues.Material and Methods: Primary Annulus Fibrosus and Nucleus Pulposus cultures were obtained from human intervertebral disc tissue. Untreated samples served as the control group, and treated samples served as the study group. Treated and untreated samples were statistically evaluated using an alpha significance value of 0.05.Results: Proliferation and gene expression decreased in the tigecycline administered cultures when compared to the control group samples (P 0.05). Conclusion: Drugs used in clinics may have side effects other than those indicated in their package insert.

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How to Cite

Emre Kaya, Y., Yilmaz, I., Karaarslan, N., Bilir, B., Yasar Sirin, D., & Ozbek, H. (2021). In-vitro evaluation of the effects of tigecycline on annulus fibrosus and nucleus pulposus . Annals of Medical Research, 27(7), 1855–1859. Retrieved from http://www.annalsmedres.org/index.php/aomr/article/view/873

Issue

Volume 27 Issue 7 (2020): July

Section

Original Articles

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