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Aim: A considerable amount of evidence is pointing out the possible contribution of neurodegeneration in the etiopathogenesis of
diabetic retinopathy (DR).
Materials and Methods: The evaluation and correlation of the neurodegenerative findings in the inner retinal layers with the choroid
of patients with type 2 diabetes mellitus (DM) without DR via optic coherence tomography (OCT) are aimed in this study.
Results: Neuronal and axonal loss seems to occur early in DM before the ophthalmoscopic vascular changes.
Conclusion: Strict glycemic control, in addition to neuroprotective measures in this pre-retinopathy phase may offer a promising
treatment choice by decelerating the progression to overt retinopathy.
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