Could SCUBE be used as a therapeutic target in rheumatoid arthritis?

Authors

  • Nurce Cilesizoglu Yavuz Giresun University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Giresun, Türkiye
  • Erhan Capkin Karadeniz Technical University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Trabzon, Türkiye
  • Asim Orem Karadeniz Technical University, Faculty of Medicine, Department of Medical Biochemistry, Trabzon, Türkiye
  • Ahmet Mentese Karadeniz Technical University, Faculty of Medicine, Department of Medical Biochemistry, Trabzon, Türkiye
  • Diler Us Altay Ordu University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ordu, Türkiye

Keywords:

Rheumatoid arthritis, Angiogenesis, SCUBE

Abstract

Aim:  To investigate the levels of signal peptide-CUB-EGF domain-containing protein (SCUBE 1 and 3) in rheumatoid arthritis (RA).

Materials and Methods: Twenty eight RA patients and 28 healthy volunteers were included in the study. SCUBE-1, SCUBE-3, Vascular Endothelial Growth Factor (VEGF), Matrix Metalloproteinase-9 (MMP-9), CD-40L, Interleukin-6 (IL-6) levels, which are important markers in angiogenesis, were measured twice, at baseline and after the treatment.

Results: Compared to the healthy group, only MMP-9, one of the angiogenesis markers, was elevated in the patient group (p>0.05). After treatment, a significant decrease was observed in VEGF levels (p<0.05), while SCUBE-1, SCUBE-3, IL-6, CD-40 and MMP-9 levels remained at similar levels (p>0.05).

Conclusion: In our study, RA patients responded to treatment with clinical improvements. Although there were differences in the levels of MMP and VEGF, there was no association with the disease in SCUBE.

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Published

2023-10-25

Issue

Vol. 30 No. 10 (2023): October

Section

Original Articles

License

Copyright (c) 2023 Annals of Medical Research

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

CC Attribution-NonCommercial-NoDerivatives 4.0

How to Cite

1.
Could SCUBE be used as a therapeutic target in rheumatoid arthritis?. Ann Med Res [Internet]. 2023 Oct. 25 [cited 2025 Apr. 26];30(10):1196-9. Available from: http://www.annalsmedres.org/index.php/aomr/article/view/4550